Original Article

Pediatric Liver Transplantation Outcomes for Metabolic and Nonmetabolic Diseases in Turkey: A Single Center Experience

10.4274/jpr.82713

  • Miray Karakoyun
  • Ebru Canda
  • Sirmen Kizilcan
  • Orkan Ergun
  • Murat Kılıç
  • Funda Çetin
  • Sema Aydoğdu

Received Date: 13.03.2018 Accepted Date: 15.10.2018 J Pediatr Res 0;0(0):0-0 [e-Pub]

Aim:

Liver transplantation (LT) is performed for several indications in the pediatric population, including malignancy and acute hepatic failure among others. LT has become an important treatment alternative for metabolic diseases. In most pediatric transplant centers, metabolic liver disease is the second most common indication for liver transplantation after biliary atresia. Our studies aim is to compare the post-transplant outcomes of the patients with metabolic and other liver diseases in our transplant program.

Materials and Methods:

One hundred eighty-nine patients who underwent liver transplantation between 1997 and 2015 due to metabolic diseases and acute or chronic liver failure were included in the study.

Results:

We enrolled 189 patients in our study. 54% (n = 102) male and 46% (n = 87) female patients were included in the study. Metabolic disease group include 56 patients. Progressive familial intrahepatic cholestasis (PFIC) is the most common disease among metabolic diseases resulting in LT Wilson disease takes second place. Post-transplant immunosuppression was similar for both groups. Although there was no difference in both groups, regarding onset of the post-transplant complications for graft type, recipient age. Biliary and portal vein complications were most particularly defined in the group with nonmetabolic diseases. There was no significant difference in survival between the two groups.

Conclusion:

Liver transplantation is an important treatment option for acute hepatic failure and end-stage liver diseases. In addition, liver transplantation is an alternative treatment option for some metabolic diseases.

Keywords: Complications, non-metabolic diseases, metabolic diseases, liver, survival, transplantation