Thioguanine-Related Chronic Hepatotoxicity in a Child with Acute Myeloid Leukemia: A Case Report and Review
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Case Report

Thioguanine-Related Chronic Hepatotoxicity in a Child with Acute Myeloid Leukemia: A Case Report and Review

J Pediatr Res 2015;2(2):102-104 DOI: 10.4274/jpr.69885
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Abstract

The association between 6-Thioguanine (6-TG) treatment and drug-induced liver injury has been reported since 1976. Recent reports have suggested that treatment of patients with 6-TG can lead to chronic hepatotoxicity and portal hypertension. Most of the cases reported to have 6-TG related hepatotoxicity had acute lymphoblastic leukemia or inflammatory bowel disease. In this case report, we discussed the diagnosis and approach in an acute myeloid leukemia patient who developed 6-TG related chronic hepatotoxicity.

Keywords: 6-Thioguanine, hepatotoxicity, leukemia