Case Report

Thioguanine-Related Chronic Hepatotoxicity in a Child with Acute Myeloid Leukemia: A Case Report and Review


  • Tuba Hilkay Karapınar
  • Yeşim Oymak
  • Çiğdem Ecevit
  • Funda Yılmaz
  • Miray Karakoyun
  • Yılmaz Ay
  • Canan Vergin

Received Date: 19.12.2014 Accepted Date: 12.03.2015 J Pediatr Res 2015;2(2):102-104

The association between 6-Thioguanine (6-TG) treatment and drug-induced liver injury has been reported since 1976. Recent reports have suggested that treatment of patients with 6-TG can lead to chronic hepatotoxicity and portal hypertension. Most of the cases reported to have 6-TG related hepatotoxicity had acute lymphoblastic leukemia or inflammatory bowel disease. In this case report, we discussed the diagnosis and approach in an acute myeloid leukemia patient who developed 6-TG related chronic hepatotoxicity.

Keywords: 6-Thioguanine, hepatotoxicity, leukemia

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